Lipid Profile Status in Chronic Obstructive Pulmonary Disease and Association with Interleukin 8

Background: There are several conflicting pictures found about blood lipid profile parameters in Chronic Obstructive Pulmonary Disease.

Aim: The present study was conducted to evaluate the exact profile of lipid status in COPD and as inflammation has been implicated in the pathogenesis of COPD, is there any association between inflammatory chemokines and lipid profile.

Methods: From February 2011 to May 2013 five hundred fifty two patients with COPD presented to Burdwan Medical College and Hospital and 521 subjects having no COPD as age and sex-matched control entered to the study. Diagnosis of COPD was confirmed according to clinical findings and pulmonary function test. Lipid parameters and IL8 in serum were measured in all subjects.

Results: The mean level of TG was 148.32±12.18 mg/dl and 134.54±11.78 mg/dl in COPD patients and healthy control, respectively. (p<0.001). The mean level of TC was 186.46±22.91 mg/dl and 173.77±15.21 in COPD patients and healthy control respectively (p<0.001). LDL level mean value was 118.91±12.92 mg/dl and 118.91±12.92 mg/dl in COPD patients and control respectively (p<0.001). The mean value of HDL showed 33.46±4.69 mg/dl in COPD patients and 38.38±5.22 mg/dl in control (p = 0.034). Regression analysis was showed IL8 was statistically significantly correlated with TC (r = 0.785, p <0.001), TG (r = 0.871, p<0.001), LDL (r = 0.882, p<0.001), VLDL (r = 0.679, p=0.016) and HDL (r = -0.681, p=0.012),

Conclusion: COPD patients showed significantly higher serum levels of TC, TG, LDL, IL8 and serum concentrations of HDL were also decreased significantly compared to controls. Moreover, lipid profile parameters were well correlated with serum IL8.