Association of Life's Simple 7 with mild cognitive impairment in community-dwelling older adults in China: a cross-sectional study

Yang, Mengshu and Liu, Yilan and Hu, Xiuzhen and Ren, Dianxu and Yang, Qing and Mao, Jing and Chen, Jing (2023) Association of Life's Simple 7 with mild cognitive impairment in community-dwelling older adults in China: a cross-sectional study. Frontiers in Aging Neuroscience, 15. ISSN 1663-4365

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Abstract

Background: Life's Simple 7 (LS7), a metric composed of seven intervenable cardiovascular risk factors, is initiated by the American Heart Association to improve cardiovascular health. The components of LS7 have been reported as risk factors for dementia. However, few studies investigated the association between LS7 metric and mild cognitive impairment (MCI).

Methods: The study was carried out in a primary care facility between 8 June and 10 July 2022. A total of 297 community-dwelling residents aged 65 years or older were recruited. Sociodemographic, comorbidity, and lifestyle characteristics were collected through the questionnaires, and biological parameters were obtained from blood sample examinations. Logistic regression was used to analyze the association between LS7 scores (overall, behavioral, and biological) and individual components with MCI, adjusting sex, age, education, and cardiovascular disease (CVD).

Results: In comparison with the cognitively intact group (n = 195), the MCI group (n = 102) had a lower education level and a higher proportion of hypertension. Multivariate logistic regression analysis, adjusting sex, age, education, and CVD demonstrated a significant association between MCI and overall LS7 score [odd ratio = 0.805, 95% confidence interval (0.690, 0.939)] and biological score [odd ratio = 0.762, 95% confidence interval (0.602, 0.965)].

Conclusion: Life's Simple 7 was associated with MCI in community-dwelling older adults, indicating that LS7 could be used as guidance in the prevention of dementia in the community.

Item Type: Article
Subjects: OA STM Library > Medical Science
Depositing User: Unnamed user with email support@oastmlibrary.com
Date Deposited: 10 May 2024 10:03
Last Modified: 10 May 2024 10:03
URI: http://geographical.openscholararchive.com/id/eprint/1334

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