Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress

Hakimizadeh, Elham and Zamanian, Mohammad and Giménez-Llort, Lydia and Sciorati, Clara and Nikbakhtzadeh, Marjan and Kujawska, Małgorzata and Kaeidi, Ayat and Hassanshahi, Jalal and Fatemi, Iman (2021) Calcium Dobesilate Reverses Cognitive Deficits and Anxiety-Like Behaviors in the D-Galactose-Induced Aging Mouse Model through Modulation of Oxidative Stress. Antioxidants, 10 (5). p. 649. ISSN 2076-3921

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Abstract

The long-term treatment of mice with D-galactose (D-gal) induces the overproduction of reactive oxygen species (ROS) and is a well-accepted experimental model of oxidative stress-linked cognitive disorders in physiological aging. Calcium dobesilate (CaD, Doxium®) is an established vasoactive and angioprotective drug commonly used for the clinical treatment of diabetic retinopathy and chronic venous insufficiency. It has antioxidant properties and controls vascular permeability. In the current study, we evaluated the protective effects of CaD (50 and 100 mg/kg/day p.o.) in male mice treated with D-gal (500 mg/kg/day p.o.) for six weeks. Results demonstrated that body weight loss, anxiety-like and cognitive impairments of D-gal-treated animals were reversed by CaD administration as evaluated by the measurement of mice performance in elevated plus-maze, Y-maze, and shuttle box tests. CaD treatment also inhibited the oxidative stress in aging mouse brains by decreasing malondialdehyde (MDA) levels and increasing superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) enzyme activities. These results could open new perspectives for the clinical use of CaD in treating and preventing cognitive impairment in older people.

Item Type: Article
Subjects: OA STM Library > Agricultural and Food Science
Depositing User: Unnamed user with email support@oastmlibrary.com
Date Deposited: 22 Jun 2024 09:03
Last Modified: 22 Jun 2024 09:03
URI: http://geographical.openscholararchive.com/id/eprint/1340

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