Wootton, Jack and Soutoglou, Evi (2021) Chromatin and Nuclear Dynamics in the Maintenance of Replication Fork Integrity. Frontiers in Genetics, 12. ISSN 1664-8021
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Abstract
Replication of the eukaryotic genome is a highly regulated process and stringent control is required to maintain genome integrity. In this review, we will discuss the many aspects of the chromatin and nuclear environment that play key roles in the regulation of both unperturbed and stressed replication. Firstly, the higher order organisation of the genome into A and B compartments, topologically associated domains (TADs) and sub-nuclear compartments has major implications in the control of replication timing. In addition, the local chromatin environment defined by non-canonical histone variants, histone post-translational modifications (PTMs) and enrichment of factors such as heterochromatin protein 1 (HP1) plays multiple roles in normal S phase progression and during the repair of replicative damage. Lastly, we will cover how the spatial organisation of stalled replication forks facilitates the resolution of replication stress.
Item Type: | Article |
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Subjects: | OA STM Library > Medical Science |
Depositing User: | Unnamed user with email support@oastmlibrary.com |
Date Deposited: | 09 Jan 2023 10:22 |
Last Modified: | 02 May 2024 05:58 |
URI: | http://geographical.openscholararchive.com/id/eprint/18 |